Thioether-stapled macrocyclic inhibitors of the EH domain of EHD1
نویسندگان
چکیده
منابع مشابه
Structured Cyclic Peptides That Bind the EH Domain of EHD1
EHD1 mediates long-loop recycling of many receptors by forming signaling complexes using its EH domain. We report the design and optimization of cyclic peptides as ligands for the EH domain of EHD1. We demonstrate that the improved affinity from cyclization allows fluorescence-based screening applications for EH domain inhibitors. The cyclic peptide is also unusually well-structured in aqueous ...
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Pentadentate thioether-oxime macrocyclic and quasi-macrocyclic complexes of copper(II) and nickel(II)
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry
سال: 2018
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2017.09.007